Inhibition of α-glucosidases by tea polyphenols in rat intestinal extract and Caco-2 cells grown on Transwell

Inhibition of maltase, sucrase, isomaltase and glucoamylase activity by acarbose, epigallocatechin gallate, epicatechin gallate four polyphenol-rich tea extract from white, green, oolong, black tea, were investigated using rat intestinal enzymes human Caco-2 cells. Regarding enzyme mixture, all extracts very effective in inhibiting maltase activity, but only white inhibited sucrase the inhibition was limited. Mixed-type on observed. Tea combination with produced a synergistic inhibitory effect activity. cells experiments conducted Transwells. Green show dose-dependent no The opposite observed results highlighted different response two model systems that polyphenols are good inhibitors for α-glucosidase